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Head & Neck Cancer Clinical Trials


Learn More About Head and Neck Cancer

For general information on head and neck cancer (including risk factors, symptoms, diagnosis, and treatment) visit the Cancer Council’s website:

General Enquiries

For general questions about trial availability, eligibility, or the referral process, please contact us using the form below. Our team will respond as soon as possible.

Protocol NumberCancer TypeStudy NameInterventionMechanism of ActionRecruitment StatusSponsorClinical.Trials.gov IDClick to Enquire
ADCE-T02-01Head/Neck Squamous Cell Carcinoma (HNSCC)First-in-Human, Phase 1 Study of ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Advanced Solid TumorsAntibody Drug ConjugateADC targeting a tissue factor.Open - RecruitingAdcendo ApSNCT06597721Enquire Now
SSGJ-709-101Head/Neck Squamous Cell Carcinoma (HNSCC)A Phase 1 Study to Evaluate the Safety, Pharmacokinetics and Anti-tumor Activity of SSGJ-709 in Patients With Advanced Malignant TumorsImmunotherapyAnti-PD-1 and anti-LAG-3 bispecific antibodyOpen - RecruitingShenyang Sunshine Pharmaceutical Co., LTD.NCT07016490Enquire Now
HMBD-001-103Head/Neck Squamous Cell Carcinoma (HNSCC)A Phase 1b Study to Evaluate HMBD-001 in Combination With Docetaxel With or Without Cetuximab in Participants With Advanced Squamous Non-Small Cell Lung Cancers, and HMBD-001 in Combination With Cetuximab in Participants With Advanced Squamous Cell CancersTargetedHumanized IgG1 anti-HER3 monoclonal antibody + Combo treatment for squamous HER3 Mutation.Open - RecruitingHummingbird BioscienceNCT05910827Enquire Now
GRWD5769-ST-01Head/Neck Squamous Cell Carcinoma (HNSCC)A Modular, Multi-part, Multi-arm, Open-label, Phase I/II Study to Evaluate the Safety and Tolerability of GRWD5769 Alone and in Combination With Anticancer Treatments in Patients With Solid MalignanciesImmunotherapyNovel EMITT-1Open - RecruitingGrey Wolf TherapeuticsNCT06923761Enquire Now
SR-8541A-001Head/Neck Squamous Cell Carcinoma (HNSCC)Phase 1, Dose Escalation, Safety, Tolerability, and Pharmacokinetic Study of SR-8541A (ENPP1 Inhibitor) Administered Orally as Monotherapy or in Combination With Checkpoint Inhibitors in Subjects With Advanced/Metastatic Solid TumorsTargetedENPP1 inhibitorOpen - RecruitingStingray TherapeuticsNCT06063681Enquire Now